Endotoxin Testing in Peptide

Peptides are short chains of amino acids connected by peptide (amide) bonds. The simplest peptide is dipeptide, followed by tripeptide, tetrapeptide and so on. Polypeptides are long, continuous and unbranched peptide chains. Therefore, peptides, along with nucleic acids, oligosaccharides, polysaccharides, etc., belong to the broad chemical category of biological oligomers and polymers. Peptides differ from proteins in size, and as an arbitrary reference, they can be understood to contain about 50 or fewer amino acids. Proteins are composed of one or more polypeptides arranged in a biologically functional manner, usually combined with ligands such as coenzymes and cofactors. Endotoxins are only released when the bacteria die and lyse or destroy bacterial cells by artificial methods, so they are called endotoxins. Its toxic component is mainly lipid A. Endotoxin is located in the outermost layer of the cell wall, covering the mucosin of the cell wall. The toxic effects of endotoxins of various bacteria are relatively weak and are roughly the same. They can cause fever, microcirculation disorders, endotoxin shock and disseminated intravascular coagulation. Endotoxin has heat resistance and stability, and its antigenicity is very weak! It is commonly used in the manufacture of pharmaceutical proteins, such as immunoglobulin, human albumin, or peptide products, which require endotoxin testing.

Chemical structure of peptide.Figure 1. Chemical structure of peptide.

Method

Our Services for endotoxin testing in peptide

Creative BioMart offers a corresponding endotoxin testing service. You can purchase the corresponding endotoxin removal kit and related accessory products according to the needs of your own samples. We guarantee that all instruments, water, reagents, and consumables used in the experiment are free of endotoxins, and the experiment is conducted in a clean room to ensure that low levels of endotoxins are returned to the sample. In addition, we can also provide you with related services including:

Our solutions

Project name Endotoxin testing in peptide
Testing purpose The toxic effects of endotoxins of various bacteria are roughly the same. They can cause fever, microcirculation disorders, endotoxin shock and disseminated intravascular coagulation. Endotoxin has heat resistance and stability, and its antigenicity is very weak! It is commonly used in the manufacture of pharmaceutical proteins, such as immunoglobulins, human albumin, or related products, which require endotoxin testing.
Testing cycle 3-5 days.
Service including We provide you with raw data and test reports.
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