Endotoxin Testing by Rabbit Pyrogen Test (RPT)

Pyrogen

Pyrogen refers to a pyrogenic substance that can cause an abnormal increase in body temperature of the homeotherms. It includes a bacterial pyrogen, an endogenous polymer pyrogen, an endogenous low molecular pyrogen, and a chemical pyrogen. Bacterial pyrogens are classified into endotoxins and non-endotoxin pyrogens.

Rabbit Pyrogen Test (RPT)

Pyrogen testing is one of the important inspection items to ensure the safety of drugs. In 1923, Seibert first proposed the method of detecting pyrogens in rabbits. RPT can objectively reflect the characteristics of pyrogens in various drugs and biological products in the body, and can intuitively reflect the temperature rise of experimental rabbits caused by pyrogens in drugs, play an important role to ensure drug quality and drug safety.

Method of RPT Test

By injecting a certain dose of the test substance into the body of the rabbit intravenously, observing the rise of rabbit temperature within a specified time to determine whether the limit of pyrogen contained in the test substance met the requirements.

Advantages of RPT Test:

• Can reflect the complex heating process of mammals caused by pyrogens.
• Can detect the pyrogen of bacterial endotoxin and the pyrogen of non-bacterial endotoxin.
• Suitable for examining a variety of pyrogens.
• Advanced instruments and equipments.
• The sensitivity of the rabbit pyrogen test is 0. 001 μg /mL.
• The test result is close to the real situation of the human body.

Our Advantages:

• Multiple kinds of samples can be tested, including but not limited to:

A. Medicine
B. Biological products
C. Medical devices
D. Drug packaging materials

• Ensure the reliability of test results.
• Repeat 3 tests in the workflow to ensure repeatability of test results.
• Mature and unified operation process to ensure efficient and fast feedback of test results.
• Provide endotoxin testing services for a variety of samples and equipment.
• Customize the exclusive testing service according to your requirements.

Creative BioMart provides you with a rabbit pyrogen test services. We have a team of professional and well-equipped scientists dedicated to working with researchers around the world to meet customer requirements and ensure quality of service. If you are interested in our services, please contact us for more details.