Clinically Relevant Endotoxin Testing

Creative BioMart is one of the recognized experts in endotoxin testing. We have many years of experience in endotoxin testing and advanced production systems and equipment to provide fast and satisfactory endotoxin testing services according to customer needs.

There are many situations in clinical application that require endotoxin testing, otherwise it will cause serious consequences. For example, in the sterilization process of the hemodialysis equipment system, dialysis water, dialysis concentration and dialysate that exceed the endotoxin level will bring endotoxin into the blood of uremic patients, causing endotoxemia in uremic patients. Endotoxin acts on phagocytes, neutrophils, endothelial cells, platelets, the complement system and the coagulation system, and induces tumor necrosis factor-α (TNF-a) and leukocytes. Bioactive substances such as interleukins (IL-1, see Figure 1), IL-6 and IL-8, histamine and kallikrein can cause insufficient capillary perfusion of tissues and organs, resulting in hypoxia and acidosis. High concentrations of endotoxin can also activate alternative complement pathways, trigger high fever, low blood pressure and activate the coagulation system, leading to disseminated intravascular coagulation. In severe cases, it may cause endotoxin shock or even death, characterized by microcirculation failure and hypotension. After the cause is identified, the infected person should be given anti-infective treatment.

Method

Our Services for endotoxin testing in Clinically relevant endotoxin testing

Creative BioMart offers a corresponding endotoxin testing service. You can purchase the corresponding endotoxin removal kit and related accessory products according to the needs of your own samples. We guarantee that all instruments, water, reagents, and consumables used in the experiment are free of endotoxins, and the experiment is conducted in a clean room to ensure that low levels of endotoxins are returned to the sample. In addition, we can also provide you with related services including:

Our solutions

Project name Clinically relevant endotoxin testing
Testing purpose In the clinic, there are many situations that require endotoxin testing, otherwise it will cause serious consequences. For example, in the sterilization process of the hemodialysis equipment system, the dialysis water exceeding the endotoxin level, the dialysis concentration and the dialysate will bring the endotoxin into the blood of uremic patients, thereby causing endotoxemia in uremic patients.
Testing cycle 3-5 days.
Service including We provide you with raw data and test reports.
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