Introduction of Endotoxin-free Purification Resins

Detoxification of endotoxins from protein or antibody samples before cell transfection or animal injection The presence of endotoxins in biologically derived products prepared for research, vaccine, or therapeutic use is a problem due to the variety of biological responses to these molecules Diverse and potentially harmful. Endotoxin contamination of proteins purified from bacterial cultures is caused by residual lipopolysaccharide (LPS) derived from the outer cell membrane of Gram-negative bacteria. Transfection of endotoxin-contaminated protein samples into cells or injection into animal hosts can elicit a strong immune response. Endotoxin purification resin is an affinity chromatography resin that efficiently removes bacterial endotoxins, mainly for aqueous solutions containing low or high-molecular-weight substances such as proteins and nucleic acids.

Figure 1. Transparent cell with biotechnology.

Features of Our Products

• High Binding Capacity
• Minimal leaching of the ligand
• Flow rate tested
• Highly purified from endotoxin-free serum, ascitic fluid, and cell culture medium

Advantages of Our Products

• Meet all requirements for industrial applications and can be easily integrated into early or late purification processes.
• High recovery and low sample loss
• Strong chemical and physical stability
• High flow rate, hydrophilicity, and high gel strength
• Provide higher protein binding capacity and minimize the leaching of recombinant proteins
• Effectively reduce or remove part of endotoxin in serum or ascites samples

Applications of Our Products

• Rapid purification of IgG from humans, mice, rats, goats, rabbits, and other species in serum, ascitic fluid, and cell culture medium
• Immunoprecipitation
• Reduce or remove a certain amount of endotoxin in serum or ascitic fluid samples

Creative BioMart is committed to providing a series of high-quality endotoxin-free purification resins for the removal of endotoxin in scientific research institutes and biotechnology studies to meet experimental needs. You can quickly find the reagent you need by searching keywords such as CAT number or product name. Please tell us your product needs, we will provide you with a comprehensive consultation. If you have any questions, please feel free to contact us.