Alternariol

Specification

Cat# INH-006
Description/Features Mycotoxin. Phytotoxin. Shows cytotoxic, teratogenic, mutagenic and genotoxic properties by DNA intercalation. Induces several types of DNA damage, including oxidative DNA damage, single-stranded DNA breaks (SSB) and double-strand, through AOH-induced ROS production and interaction with DNA topoisomerase. Inhibits the activity of topoisomerase IIα in mammalian cells. Induces cell growth arrest in G2/M phase. GSK-3β inhibitor (sub-μM IC50 values). Antiviral activity (herpes simplex). Hepatitis C NS3-4A protease inhibitor. Induces cytochrome P450 1A1 expression and apoptosis in mouse hepatoma cells.
Origin Alternaria sp
Forms Light brown solid.
Purity ≥98% (HPLC)
Formula C14H10O5
MW 258.2
CAS 641-38-3
Solubility Soluble in DMSO (20mg/ml) or DMF. Slightly soluble in acetone (1mg/ml).
Identity Determined by 1H-NMR.
Synonyms AOH; NSC 638263; 3,4',5-Trihydroxy-6'-methyldibenzo-α-pyrone
Storage Stable for at least 1 year after receipt when stored at +4°C. After reconstitution protect from light at -20°C.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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