Fibroblast growth factor 7 (FGF7) is a secreted protein which is mainly located in epithelial cells and belongs to the heparin-binding growth factors family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF7 is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. It is possible major paracrine effector of normal epithelial cell proliferation.
Short Name: |
Recombinant Human FGF7 Protein, low endotoxin |
Cat#: |
EPLE-12H |
Recombinant: |
E. coli |
Abbr: |
FGF7(Human) |
Alias: |
FGF7; fibroblast growth factor 7; fibroblast growth factor 7 (keratinocyte growth factor); keratinocyte growth factor; KGF; FGF-7; heparin-binding growth factor 7; HBGF-7; |
Type: |
F |
similar: |
FGF7 |
Product Overview: |
Recombinant Human Fibroblast Growth Factor 7/Keratinocyte growth factor is produced by our E.coli expression system and the target gene encoding Cys32-Thr194 is expressed. |
Source: |
E.coli |
Species: |
Human |
Molecular Mass: |
Mol Mass: 18.9 kDa AP Mol Mass: 17 kDa, reducing conditions. |
Protein length: |
Cys32-Thr194 |
Endotoxin: |
Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test. |
Purity: |
Greater than 95% as determined by reducing SDS-PAGE. |
Storage: |
Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days. Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months. |
Storage Buffer: |
Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, pH8.0. |
Reconstitution: |
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Gene Name: |
FGF7 fibroblast growth factor 7 [ Homo sapiens ] |
Official Symbol: |
FGF7 |
Synonyms: |
FGF7; fibroblast growth factor 7; fibroblast growth factor 7 (keratinocyte growth factor); keratinocyte growth factor; KGF; FGF-7; heparin-binding growth factor 7; HBGF-7; |
GeneID: |
2252 |
mRNA Refseq: |
NM_002009 |
Protein Refseq: |
NP_002000 |
MIM: |
148180 |
UniProt ID: |
P21781 |
References: |
1. SOX9 inactivation affects the proliferation and differentiation of human lung organoids[J]. Lian Li. et al. Stem Cell Research & Therapy. 2021. |
Figure 1 |
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