Fibroblast growth factor 7 (FGF7) is a secreted protein which is mainly located in epithelial cells and belongs to the heparin-binding growth factors family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF7 is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. It is possible major paracrine effector of normal epithelial cell proliferation.
| Short Name: |
Recombinant Human FGF7 Protein, low endotoxin |
| Cat#: |
EPLE-12H |
| Recombinant: |
E. coli |
| Abbr: |
FGF7(Human) |
| Type: |
F |
| Product Overview: |
Recombinant Human Fibroblast Growth Factor 7/Keratinocyte growth factor is produced by our E.coli expression system and the target gene encoding Cys32-Thr194 is expressed. |
| Source: |
E.coli |
| Species: |
Human |
| Molecular Mass: |
Mol Mass: 18.9 kDa
AP Mol Mass: 17 kDa, reducing conditions. |
| Protein length: |
Cys32-Thr194 |
| Endotoxin: |
Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test. |
| Purity: |
Greater than 95% as determined by reducing SDS-PAGE. |
| Storage: |
Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days.
Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months. |
| Storage Buffer: |
Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, pH8.0. |
| Reconstitution: |
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Gene Name: |
FGF7 fibroblast growth factor 7 [ Homo sapiens ] |
| Official Symbol: |
FGF7 |
| Synonyms: |
FGF7; fibroblast growth factor 7; fibroblast growth factor 7 (keratinocyte growth factor); keratinocyte growth factor; KGF; FGF-7; heparin-binding growth factor 7; HBGF-7; |
| GeneID: |
2252 |
| mRNA Refseq: |
NM_002009 |
| Protein Refseq: |
NP_002000 |
| MIM: |
148180 |
| UniProt ID: |
P21781 |
| References: |
1. SOX9 inactivation affects the proliferation and differentiation of human lung organoids[J]. Lian Li. et al. Stem Cell Research & Therapy. 2021. |
| Figure 1 |
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