Fibroblast growth factor 4(FGF-4) is a heparin binding member of the FGF family. The human FGF4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C-terminus. Mature human FGF4 shares 91%, 82%, 94% and 91% aa identity with mouse, rat, canine and bovine FGF4, respectively. Human FGF-4 has been shown to exhibit cross species activity. Expression of FGF-4 and its receptors, FGF R1c, 2c, 3c and 4, is spatially and temporally regulated during embryonic development. FGF-4 is proposed to play a physiologically relevant role in human embryonic stem cell selfrenewal. It promotes stem cell proliferation, but may also aid differentiation depending on context and concentration, and is often included in embryonic stem cell media in vitro. FGF-4 is mitogenic for fibroblasts and endothelial cells in vitro and has autocrine transforming potential. It is a potent angiogenesis promoter in vivo and has been investigated as therapy for coronary artery disease.
| Short Name: |
Recombinant Mouse Fgf4 Protein, low endotoxin |
| Cat#: |
EPLE-11M |
| Recombinant: |
E. coli |
| Abbr: |
Fgf4(Mouse) |
| Alias: |
FGF4; fibroblast growth factor 4; HBGF-4; K-fibroblast growth factor; heparin-binding growth factor 4; KS3; hst; Fgfk; Hst1; kFGF; Fgf-4; hst-1; Hstf-1; MGC129266; MGC129267; |
| Type: |
F |
| similar: |
Fgf4 |
| Product Overview: |
Recombinant Mouse Fibroblast Growth Factor 4 is produced by our E.coli expression system and the target gene encoding Ser67-Leu202 is expressed. |
| Source: |
E.coli |
| Species: |
Mouse |
| Molecular Mass: |
Mol Mass: 15.2 kDa
AP Mol Mass: 15 kDa, reducing conditions. |
| Protein length: |
Ser67-Leu202 |
| Endotoxin: |
Less than 0.001 ng/μg (0.01 EU/μg) as determined by LAL test. |
| Purity: |
Greater than 95% as determined by reducing SDS-PAGE. |
| Storage: |
Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days.
Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months. |
| Storage Buffer: |
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| Reconstitution: |
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Gene Name: |
Fgf4 fibroblast growth factor 4 [ Mus musculus ] |
| Official Symbol: |
Fgf4 |
| Synonyms: |
FGF4; fibroblast growth factor 4; HBGF-4; K-fibroblast growth factor; heparin-binding growth factor 4; KS3; hst; Fgfk; Hst1; kFGF; Fgf-4; hst-1; Hstf-1; MGC129266; MGC129267; |
| GeneID: |
14175 |
| mRNA Refseq: |
NM_010202 |
| Protein Refseq: |
NP_034332 |
| UniProt ID: |
P11403 |
| Figure 1 |
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