Bone Morphogenetic Protein-2 (BMP-2) is one of the bone-growth regulatory factors that belong to the transforming growth factor-beta (TGF-beta) superfamily of proteins. BMPs are synthesized as large precursor molecules, which are cleaved by proteolytic enzymes. The active form of BMP-2 can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
| Short Name: | Recombinant Human BMP2 Protein, low endotoxin |
| Cat#: | EPLE-04H |
| Recombinant: | E. coli |
| Abbr: | BMP2(Human) |
| Alias: | BMP2; bone morphogenetic protein 2; BMP2A; BMP-2A; bone morphogenetic protein 2A; BDA2; |
| Type: | B |
| similar: | BMP2 |
| Product Overview: | Recombinant Human/Mouse/Rat Bone Morphogenetic Protein 2 is produced by our E.coli expression system and the target gene encoding Gln283-Arg396 is expressed. |
| Source: | E.coli |
| Species: | Human |
| Molecular Mass: | Mol Mass: 13.3 kDa AP Mol Mass: 13 kDa, reducing conditions. |
| Protein length: | Gln283-Arg396 |
| Endotoxin: | Less than 0.001 ng/μg (0.01 EU/μg) as determined by LAL test. |
| Purity: | Greater than 95% as determined by reducing SDS-PAGE. |
| Storage: | Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days. Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months. |
| Storage Buffer: | Lyophilized from a 0.2 μm filtered solution of 10mM HAc-NH4Ac, 4% D-Mannitol, pH 4.0. |
| Reconstitution: | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in 50mM Acetic Acid. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Gene Name: | BMP2 bone morphogenetic protein 2 [ Homo sapiens ] |
| Official Symbol: | BMP2 |
| Synonyms: | BMP2; bone morphogenetic protein 2; BMP2A; BMP-2A; bone morphogenetic protein 2A; BDA2; |
| GeneID: | 650 |
| mRNA Refseq: | NM_001200 |
| Protein Refseq: | NP_001191 |
| MIM: | 112261 |
| UniProt ID: | P12643 |
| References: | 1. PKC-δ deficiency in B cells displays osteopenia accompanied with upregulation of RANKL expression and osteoclast–osteoblast uncoupling[J]. Shangfu Li. et al. Cell Death and Disease. 2020. 2. Efficient catechol functionalization of biopolymeric hydrogels for effective multiscale bioadhesion[J]. KunyuZhang. et al. Materials Science and Engineering: C. 2019. 3. Biological activity of a nanofibrous barrier membrane containing bone morphogenetic protein formed by core-shell electrospinning as a sustained delivery vehiclet[J]. Huiyong Zhu. et al. J Biomed Mater Res. 2013. |
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