Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits.
| Short Name: |
Recombinant Human INHBA Protein, low endotoxin |
| Cat#: |
EPLE-02H |
| Recombinant: |
Human Cells |
| Abbr: |
INHBA(Human) |
| Alias: |
INHBA; inhibin, beta A; inhibin, beta A (activin A, activin AB alpha polypeptide); inhibin beta A chain; Inhibin, beta-1; activin beta-A chain; FSH-releasing protein; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; EDF; FRP; |
| Type: |
I |
| similar: |
INHBA |
| Product Overview: |
Recombinant Human/Mouse/Rat Activin A is produced by our Mammalian expression system and the target gene encoding Gly311-Ser426 is expressed. |
| Source: |
Human Cells |
| Species: |
Human |
| Bio-activity: |
Measured by its ability to induce SMAD signaling in 293-Activin A Res cells. The ED50 for this effect is 1.3 ng/mL. |
| Molecular Mass: |
Mol Mass: 13 kDa
AP Mol Mass: 15 kDa, reducing conditions. |
| Protein length: |
Gly311-Ser426 |
| Endotoxin: |
Less than 0.001 ng/μg (0.01 EU/μg) as determined by LAL test. |
| Purity: |
Greater than 95% as determined by reducing SDS-PAGE. |
| Storage: |
Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days.
Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months. |
| Storage Buffer: |
Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
| Reconstitution: |
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Gene Name: |
INHBA inhibin, beta A [ Homo sapiens ] |
| Official Symbol: |
INHBA |
| Synonyms: |
INHBA; inhibin, beta A; inhibin, beta A (activin A, activin AB alpha polypeptide); inhibin beta A chain; Inhibin, beta-1; activin beta-A chain; FSH-releasing protein; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; EDF; FRP; |
| GeneID: |
3624 |
| mRNA Refseq: |
NM_002192 |
| Protein Refseq: |
NP_002183 |
| MIM: |
147290 |
| UniProt ID: |
P08476 |
| References: |
1. Inhibition of MTA2 and MTA3 induces mesendoderm specification of human embryonic stem cells[J]. Yu You. et al. Biochemical and Biophysical Research Communications. 2021.
2. Targeting thymidine phosphorylase as a potential therapy for bone loss associated with periprosthetic osteolysis[J]. Gen Matsumae. et al. Bioengineering & Translational Medicine. 2021. |
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