| Cat#: | INH-006 |
| Description/Features: | Mycotoxin. Phytotoxin. Shows cytotoxic, teratogenic, mutagenic and genotoxic properties by DNA intercalation. Induces several types of DNA damage, including oxidative DNA damage, single-stranded DNA breaks (SSB) and double-strand, through AOH-induced ROS production and interaction with DNA topoisomerase. Inhibits the activity of topoisomerase IIα in mammalian cells. Induces cell growth arrest in G2/M phase. GSK-3β inhibitor (sub-μM IC50 values). Antiviral activity (herpes simplex). Hepatitis C NS3-4A protease inhibitor. Induces cytochrome P450 1A1 expression and apoptosis in mouse hepatoma cells. |
| Origin: | Alternaria sp |
| Forms: | Light brown solid. |
| Purity: | ≥98% (HPLC) |
| Formula: | C14H10O5 |
| MW: | 258.2 |
| CAS: | 641-38-3 |
| Solubility: | Soluble in DMSO (20mg/ml) or DMF. Slightly soluble in acetone (1mg/ml). |
| Identity: | Determined by 1H-NMR. |
| Synonyms: | AOH; NSC 638263; 3,4',5-Trihydroxy-6'-methyldibenzo-α-pyrone |
| Storage: | Stable for at least 1 year after receipt when stored at +4°C. After reconstitution protect from light at -20°C. |
